Title : TRPV4-Rho signaling drives cytoskeletal and focal adhesion remodeling in trabecular meshwork cells.

Pub. Date : 2021 Jun 1

PMID : 33788628






3 Functional Relationships(s)
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1 Stretch-induced activation of the small GTPase RhoA, and tyrosine phosphorylations of focal adhesion proteins paxillin, focal adhesion kinase (FAK), vinculin and zyxin were time-dependently inhibited by ROCK inhibitor Y-27632, and by HC-067047, an antagonist of transient receptor potential vanilloid 4 (TRPV4) channels. Tyrosine paxillin Homo sapiens
2 Stretch-induced activation of the small GTPase RhoA, and tyrosine phosphorylations of focal adhesion proteins paxillin, focal adhesion kinase (FAK), vinculin and zyxin were time-dependently inhibited by ROCK inhibitor Y-27632, and by HC-067047, an antagonist of transient receptor potential vanilloid 4 (TRPV4) channels. Y 27632 paxillin Homo sapiens
3 Stretch-induced activation of the small GTPase RhoA, and tyrosine phosphorylations of focal adhesion proteins paxillin, focal adhesion kinase (FAK), vinculin and zyxin were time-dependently inhibited by ROCK inhibitor Y-27632, and by HC-067047, an antagonist of transient receptor potential vanilloid 4 (TRPV4) channels. HC-067047 paxillin Homo sapiens