Title : Dysfunctional EGFR and oxidative stress-induced PKD1 signaling drive formation of DCLK1+ pancreatic stem cells.

Pub. Date : 2021 Jan 22

PMID : 33521594






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Mimicking blockage of EGFR with erlotinib in PanIN organoid culture or in p48cre;KrasG12D mice led to a significant increase in DCLK1+ PanIN cells. Erlotinib Hydrochloride doublecortin-like kinase 1 Mus musculus
2 As a mechanism of how EGFR inhibition leads to formation of DCLK1+ cells, we identify an increase in hydrogen peroxide contributing to activation of Protein Kinase D1 (PKD1). Hydrogen Peroxide doublecortin-like kinase 1 Mus musculus