Title : Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells.

Pub. Date : 2021 Apr

PMID : 33472949






2 Functional Relationships(s)
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1 Crosstalk between YAP and RAR-RXR drives expression of stemness genes to promote 5-FU resistance and self-renewal in colorectal cancer cells. Fluorouracil retinoid X receptor alpha Homo sapiens
2 Moreover, activation of the YAP/RAR-RXR crosstalk in CRC cells promoted RAR self-activation loops via vitamin A metabolism, RA and active RAR ligands generated by ALDH1A3. Vitamin A retinoid X receptor alpha Homo sapiens