Pub. Date : 2021 Feb 19
PMID : 33450246
3 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | In agreement with these results, CUX1 knockdown decreases BER completion in cell extracts and causes an increase in the number of abasic sites in genomic DNA following temozolomide treatment. | Temozolomide | cut like homeobox 1 | Homo sapiens | ||
| 2 | We also show that CUT domains stimulate bypass of intrastrand G-crosslinks by Pol beta in vitro, while the resistance of cancer cells to cisplatin treatment is reduced by CUX1 knockdown but restored by ectopic expression of CUT domains. | Cisplatin | cut like homeobox 1 | Homo sapiens | ||
| 3 | Altogether our results establish CUX1 as an important auxiliary factor that stimulates multiple steps of base excision repair, from the recognition and removal of altered bases to the addition of new nucleotides and removal of 5"-deoxyribose phosphate required for ligation and BER completion. | 5"-deoxyribose phosphate | cut like homeobox 1 | Homo sapiens | ||