Title : Benzo[a]pyrene induces fibrotic changes and impairs differentiation in lung stem cells.

Pub. Date : 2021 Mar 1

PMID : 33429317






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here, we provide evidence that benzo[a]pyrene (BaP), a major toxic PAH, induces fibrotic changes with a loss of alpha-1,6-fucosylation in CD54+CD157+CD45- cells (lung stem cells). Benzo(a)pyrene bone marrow stromal cell antigen 1 Homo sapiens
2 Here, we provide evidence that benzo[a]pyrene (BaP), a major toxic PAH, induces fibrotic changes with a loss of alpha-1,6-fucosylation in CD54+CD157+CD45- cells (lung stem cells). Benzo(a)pyrene bone marrow stromal cell antigen 1 Homo sapiens
3 Finally, it was observed that BaP impairs the spheroid formation and the podoplanin expression of CD54+CD157+CD45- cells, indicating that BaP suppresses the differentiation of lung stem cells. Benzo(a)pyrene bone marrow stromal cell antigen 1 Homo sapiens
4 Finally, it was observed that BaP impairs the spheroid formation and the podoplanin expression of CD54+CD157+CD45- cells, indicating that BaP suppresses the differentiation of lung stem cells. Benzo(a)pyrene bone marrow stromal cell antigen 1 Homo sapiens
5 Taken together, our findings reveal specific BaP-induced injuries in CD54+CD157+CD45- cells. Benzo(a)pyrene bone marrow stromal cell antigen 1 Homo sapiens