Pub. Date : 2021
PMID : 33309945
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cholangiopathy and biliary fibrosis in Cyp2c70-deficient mice are fully reversed by ursodeoxycholic acid. | Ursodeoxycholic Acid | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 2 | Cyp2c70-ablation in mice prevents synthesis of mouse/rat-specific muricholic acids (MCAs), but potential (patho)physiological consequences of their absence are unknown. | muricholic acid | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 3 | Cyp2c70-ablation in mice prevents synthesis of mouse/rat-specific muricholic acids (MCAs), but potential (patho)physiological consequences of their absence are unknown. | muricholic acid | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 4 | RESULTS: Cyp2c70-/- mice were devoid of MCAs and showed high abundances of chenodeoxycholic and lithocholic acids. | chenodeoxycholic | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 5 | RESULTS: Cyp2c70-/- mice were devoid of MCAs and showed high abundances of chenodeoxycholic and lithocholic acids. | Lithocholic Acid | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 6 | Addition of 0.1% ursodeoxycholic acid to the diet fully normalized hepatic and intestinal functions in female Cyp2c70-/- mice. | Ursodeoxycholic Acid | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 7 | These consequences of Cyp2c70-deficiency are restored by treatment with UDCA, indicating a role of BA hydrophobicity in disease development. | Ursodeoxycholic Acid | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 8 | These consequences of Cyp2c70-deficiency are restored by treatment with UDCA, indicating a role of BA hydrophobicity in disease development. | Bile Acids and Salts | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |