Title : Specific inhibitors for prolyl endopeptidase and their anti-amnesic effect.

Pub. Date : 1987 Dec

PMID : 3330562






1 Functional Relationships(s)
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1 Among the compounds tested, Z-Gly-Pro-CH2Cl, Z-Val-prolinal, Boc-Pro-prolinal, Z-Pro-prolinal, aniracetam and pramiracetam inhibited the enzyme activities at Ki values in the order of nM to microM, and the effect of the prolinal-containing peptide derivatives was specific for prolyl endopeptidase. N-benzyloxycarbonylprolylprolinal prolyl endopeptidase Rattus norvegicus