Title : Igf3 is essential for ovary differentiation in zebrafish†.

Pub. Date : 2021 Mar 11

PMID : 33276384






1 Functional Relationships(s)
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1 Here, we found that igf3 expression could be up-regulated by estrogen in early stages of ovarian follicles as evidenced in in vitro treatment assays and cyp19a1a mutant zebrafish, and E2 failed to rescue the defects of igf3 mutants in ovarian development, suggesting that Igf3 may serve as a downstream factor of estrogen signaling in sex differentiation. Estradiol insulin-like growth factor 3 Danio rerio