Title : Forming All-Carbon Quaternary Stereocenters by Organocatalytic Aminomethylation: Concise Access to β2,2 -Amino Acids.

Pub. Date : 2020 Dec 21

PMID : 32902091






1 Functional Relationships(s)
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1 We report here a novel organocatalytic enantioselective aminomethylation of ketenes with stable and readily available N,O-acetals, providing beta 2,2 -amino esters bearing an all-carbon quaternary stereogenic center in high enantiomeric ratios with a catalytic amount of chiral phosphoric acid. ketene immunoglobulin kappa variable 3-25 (pseudogene) Homo sapiens