Pub. Date : 2020 Jul 23
PMID : 32573489
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Examination of COPDGene cohort identified 14 IGSF3 SNPs of which, rs1414272 and rs12066192 were directly- and rs6703791 inversely associated with COPD severity, including COPD exacerbations. | copdgene | immunoglobulin superfamily member 3 | Homo sapiens |
| 2 | IGSF3-deficient patient-derived lymphoblastoids exhibited multiple alterations in gene expression, especially in the unfolded protein response and ceramide pathways. | Ceramides | immunoglobulin superfamily member 3 | Homo sapiens |
| 3 | IGSF3-deficient lymphoblastoids had high ceramide- and sphingosine-1 phosphate-, but low glycosphingolipids- and gangliosides levels; were less apoptotic and more adherent; with marked changes in multiple TNFRSF molecules. | Ceramides | immunoglobulin superfamily member 3 | Homo sapiens |
| 4 | IGSF3-deficient lymphoblastoids had high ceramide- and sphingosine-1 phosphate-, but low glycosphingolipids- and gangliosides levels; were less apoptotic and more adherent; with marked changes in multiple TNFRSF molecules. | sphingosine 1-phosphate | immunoglobulin superfamily member 3 | Homo sapiens |
| 5 | IGSF3-deficient lymphoblastoids had high ceramide- and sphingosine-1 phosphate-, but low glycosphingolipids- and gangliosides levels; were less apoptotic and more adherent; with marked changes in multiple TNFRSF molecules. | Glycosphingolipids | immunoglobulin superfamily member 3 | Homo sapiens |
| 6 | IGSF3-deficient lymphoblastoids had high ceramide- and sphingosine-1 phosphate-, but low glycosphingolipids- and gangliosides levels; were less apoptotic and more adherent; with marked changes in multiple TNFRSF molecules. | Gangliosides | immunoglobulin superfamily member 3 | Homo sapiens |
| 7 | Similarly, IGSF3 knockdown increased ceramide in lung structural cells, rendering them more adherent, with impaired wound repair and a weakened barrier function. | Ceramides | immunoglobulin superfamily member 3 | Homo sapiens |
| 8 | These findings suggest that, by maintaining sphingolipid and membrane receptor homeostasis, IGSF3 is required for cell mobility-mediated lung injury repair. | Sphingolipids | immunoglobulin superfamily member 3 | Homo sapiens |