Pub. Date : 2020 May 28
PMID : 32463795
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | miR-378a-3p inhibits ischemia/reperfusion-induced apoptosis in H9C2 cardiomyocytes by targeting TRIM55 via the DUSP1-JNK1/2 signaling pathway. | mir-378a-3p | tripartite motif-containing 55 | Rattus norvegicus |
| 2 | TRIM55 was shown to be a target of miR-378a-3p and its downregulation inhibited the miR-378a-3p inhibitor-induced increase in cell apoptosis and JNK1/2 activation. | mir-378a-3p | tripartite motif-containing 55 | Rattus norvegicus |
| 3 | TRIM55 was shown to be a target of miR-378a-3p and its downregulation inhibited the miR-378a-3p inhibitor-induced increase in cell apoptosis and JNK1/2 activation. | mir-378a | tripartite motif-containing 55 | Rattus norvegicus |
| 4 | The protective effect of miR-378a-3p was subsequently confirmed in a rat myocardial I/R model, as evidenced by a decrease in cardiomyocyte apoptosis of cardiomyocytes, TRIM55 expression, and JNK1/2 activation. | mir-378a-3p | tripartite motif-containing 55 | Rattus norvegicus |
| 5 | Taken together, these results suggest that miR-378a-3p may protect against I/R-induced cardiomyocyte apoptosis via TRIM55/DUSP1/JNK signaling. | mir-378a-3p | tripartite motif-containing 55 | Rattus norvegicus |