Title : A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy.

Pub. Date : 2020 Jul 6

PMID : 32437499






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Synthesis of the phosphoinositide PI(3)P by the autophagic class III phosphatidylinositol-3 kinase complex I (PI3KC3-C1) and conjugation of ATG8/LC3 proteins to phagophore membranes by the ATG12-ATG5-ATG16L1 (E3) complex are two critical steps in autophagosome biogenesis, connected by WIPI2. Phosphatidylinositols autophagy related 12 Homo sapiens
2 Synthesis of the phosphoinositide PI(3)P by the autophagic class III phosphatidylinositol-3 kinase complex I (PI3KC3-C1) and conjugation of ATG8/LC3 proteins to phagophore membranes by the ATG12-ATG5-ATG16L1 (E3) complex are two critical steps in autophagosome biogenesis, connected by WIPI2. 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'D-myo-inositol-3'-phosphate) autophagy related 12 Homo sapiens