Pub. Date : 2020 Jun 1
PMID : 32292064
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We discovered a previously unrecognized, endogenous hypothalamic peptide, phoenixin (PNX, 21), identified physiologically relevant actions of the peptide in brain and pituitary gland to control reproductive hormone secretion in female rodents (17, 21) and in the process identified the previously orphaned G protein-coupled receptor, Gpr173 (17) to be a potential receptor for the peptide. | phoenixin | G protein-coupled receptor 173 | Homo sapiens |
| 2 | Importantly, losartan pretreatment blocked the effect of phoenixin on water drinking, and knockdown of Gpr173 using short interfering RNA constructs significantly attenuated water drinking in response to overnight fluid deprivation. | Water | G protein-coupled receptor 173 | Homo sapiens |