Pub. Date : 2020 Jun 1
PMID : 32126233
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The C-terminal acidic motif of Phafin2 inhibits PH domain binding to phosphatidylinositol 3-phosphate. | phosphatidylinositol 3-phosphate | pleckstrin homology and FYVE domain containing 2 | Homo sapiens |
| 2 | Phafin2 is a phosphatidylinositol 3-phosphate (PtdIns3P)-binding effector involved in endosomal and lysosomal membrane-associated signaling. | phosphatidylinositol 3-phosphate | pleckstrin homology and FYVE domain containing 2 | Homo sapiens |
| 3 | Phafin2 is a phosphatidylinositol 3-phosphate (PtdIns3P)-binding effector involved in endosomal and lysosomal membrane-associated signaling. | phosphatidylinositol 3-phosphate | pleckstrin homology and FYVE domain containing 2 | Homo sapiens |
| 4 | Both the Phafin2 PH and the FYVE domains bind PtdIns3P, although their redundant function in the protein is unclear. | phosphatidylinositol 3-phosphate | pleckstrin homology and FYVE domain containing 2 | Homo sapiens |
| 5 | Using site-directed mutagenesis and truncation constructs, we discovered that the Phafin2 FYVE domain is constitutive for PtdIns3P binding, whereas PH domain binding to PtdIns3P is autoinhibited by a conserved C-terminal acidic motif. | phosphatidylinositol 3-phosphate | pleckstrin homology and FYVE domain containing 2 | Homo sapiens |
| 6 | These findings suggest that binding of the Phafin2 PH domain to PtdIns3P in membrane compartments occurs through a highly regulated mechanism. | phosphatidylinositol 3-phosphate | pleckstrin homology and FYVE domain containing 2 | Homo sapiens |