Title : Different cellular properties and loss of nuclear signalling of porcine epidermal growth factor receptor with aging.

Pub. Date : 2020 May 1

PMID : 32001323






2 Functional Relationships(s)
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1 The study revealed the following results: 1) EGF could activate the intra-cellular signalling pathways in a time- and dose-dependent manner both in the young- and aged-pig hepatocytes, EGF induced tyrosine phosphorylation of EGFR, signal transducers and activators of transcription 3 (STAT3), protein kinase B (AKT) and extra-cellular signal-regulated kinase 1/2 (ERK1/2). Tyrosine signal transducer and activator of transcription 3 Sus scrofa
2 The study revealed the following results: 1) EGF could activate the intra-cellular signalling pathways in a time- and dose-dependent manner both in the young- and aged-pig hepatocytes, EGF induced tyrosine phosphorylation of EGFR, signal transducers and activators of transcription 3 (STAT3), protein kinase B (AKT) and extra-cellular signal-regulated kinase 1/2 (ERK1/2). Tyrosine signal transducer and activator of transcription 3 Sus scrofa