Pub. Date : 2020 Mar
PMID : 31759926
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acetate, a precursor of acetyl-CoA (a product of fatty acid beta-oxidation [FAO]), or dichloroacetate, a compound that promotes pyruvate oxidation and generation of mitochondrial acetyl-CoA, were used for metabolic intervention RESULTS: Crypt cells rapidly absorbed labeled fatty acid, and mRNA levels of Lgr5+ stem cell markers (Lgr5, Olfm4, Smoc2, Msi1, and Ascl2) were downregulated in organoids incubated with etomoxir, an inhibitor of FAO, indicating that FAO was required for renewal of ISCs. | Acetates | musashi RNA-binding protein 1 | Mus musculus |
| 2 | Acetate, a precursor of acetyl-CoA (a product of fatty acid beta-oxidation [FAO]), or dichloroacetate, a compound that promotes pyruvate oxidation and generation of mitochondrial acetyl-CoA, were used for metabolic intervention RESULTS: Crypt cells rapidly absorbed labeled fatty acid, and mRNA levels of Lgr5+ stem cell markers (Lgr5, Olfm4, Smoc2, Msi1, and Ascl2) were downregulated in organoids incubated with etomoxir, an inhibitor of FAO, indicating that FAO was required for renewal of ISCs. | Dichloroacetic Acid | musashi RNA-binding protein 1 | Mus musculus |