Pub. Date : 2020 Jan 29
PMID : 31735337
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PICK1 attenuates high glucose-induced pancreatic beta-cell death through the PI3K/Akt pathway and is negatively regulated by miR-139-5p. | Glucose | protein interacting with C kinase 1 | Mus musculus |
| 2 | Previous studies have confirmed that PICK1 is critical for both beta-cell function and glucose homeostasis. | Glucose | protein interacting with C kinase 1 | Mus musculus |
| 3 | The aim of this study was to investigate the role of PICK1 in response to high glucose-induced beta-cell dysfunction and the molecular mechanism of regulation of PICK1. | Glucose | protein interacting with C kinase 1 | Mus musculus |
| 4 | We found that overexpression of PICK1 in db/db diabetic mice significantly improved glucose tolerance and increased insulin release. | Glucose | protein interacting with C kinase 1 | Mus musculus |
| 5 | High glucose treatment of Min6 cells inhibited PICK1 expression, and overexpression of PICK1 protected against high glucose-induced pancreatic cell dysfunction. | Glucose | protein interacting with C kinase 1 | Mus musculus |
| 6 | High glucose treatment of Min6 cells inhibited PICK1 expression, and overexpression of PICK1 protected against high glucose-induced pancreatic cell dysfunction. | Glucose | protein interacting with C kinase 1 | Mus musculus |