Title : Long-term chemogenetic suppression of spontaneous seizures in a mouse model for temporal lobe epilepsy.

Pub. Date : 2019 Nov

PMID : 31608439






1 Functional Relationships(s)
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1 Next, animals were treated systemically with different single doses of clozapine-N-oxide (CNO) (1, 3, and 10 mg/kg) and clozapine (0.03 and 0.1 mg/kg) and the effect on spontaneous hippocampal seizures, hippocampal electroencephalography (EEG) power, fast ripples (FRs) and behavior in the open field test was evaluated. clozapine N-oxide biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino Mus musculus