Pub. Date : 2019 Sep 30
PMID : 31568401
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celecoxib Inhibits Hepatocellular Carcinoma Cell Growth and Migration by Targeting PNO1. | celecoxib | partner of NOB1 homolog | Homo sapiens |
| 2 | RESULTS Celecoxib inhibited HCC cell growth in vitro and in vivo, and gene chip and pathway enrichment analysis revealed that PNO1 may be the potential target of celecoxib in HCC cells. | celecoxib | partner of NOB1 homolog | Homo sapiens |
| 3 | Celecoxib significantly reduced levels of PNO1 in tumor tissue. | celecoxib | partner of NOB1 homolog | Homo sapiens |
| 4 | CONCLUSIONS Celecoxib may exert its anti-tumor activity by inhibiting PNO1, and that AKT/mTOR signaling helps mediate the oncogenic effects of PNO1. | celecoxib | partner of NOB1 homolog | Homo sapiens |