Title : Evaluation of cytochrome P450 3A4‑mediated drug‑drug interaction potential between P2Y12 inhibitors and statins.

Pub. Date : 2019 Nov

PMID : 31545497






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1 An in vivo pharmacokinetic study demonstrated that the co-administration of ticagrelor or prasugrel with simvastatin caused an increase in the principal pharmacokinetic parameters of the probe drug dapsone [area under the concentration/time curve (AUC)0-t, AUC0- and t1/2] and a decrease in clearance compared with ticagrelor, prasugrel or simvastatin alone. ticagrelor brachyury 2 Rattus norvegicus