Title : Brain Delivery of a Potent Opioid Receptor Agonist, Biphalin during Ischemic Stroke: Role of Organic Anion Transporting Polypeptide (OATP).

Pub. Date : 2019 Sep 10

PMID : 31509975






2 Functional Relationships(s)
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1 The effect of oxygen-glucose deprivation (OGD) and reperfusion on the OATP1 expression, uptake, and transport of biphalin was measured in induced pluripotent stem cells differentiated brain microvascular endothelial cells (iPSC-BMECs) in the presence and absence of an OATP1 substrate, estrone-3-sulfate (E3S). oxygen-glucose ornithine aminotransferase pseudogene 1 Homo sapiens
2 In vitro studies showed that biphalin BBB uptake and transport decreased in the presence of an OATP1 specific substrate. biphalin bbb ornithine aminotransferase pseudogene 1 Homo sapiens