Pub. Date : 2019 Jul 26
PMID : 31186346
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TAZ-KO cells exhibited decreased flux of [U-13C]glucose to [13C]acetyl-CoA and M2 and M4 isotopomers of tricarboxylic acid (TCA) cycle intermediates. | Glucose | tafazzin, phospholipid-lysophospholipid transacylase | Mus musculus |
| 2 | TAZ-KO cells exhibited decreased flux of [U-13C]glucose to [13C]acetyl-CoA and M2 and M4 isotopomers of tricarboxylic acid (TCA) cycle intermediates. | [13c]acetyl-coa | tafazzin, phospholipid-lysophospholipid transacylase | Mus musculus |
| 3 | TAZ-KO cells exhibited decreased flux of [U-13C]glucose to [13C]acetyl-CoA and M2 and M4 isotopomers of tricarboxylic acid (TCA) cycle intermediates. | Tricarboxylic Acids | tafazzin, phospholipid-lysophospholipid transacylase | Mus musculus |
| 4 | TAZ-KO cells exhibited decreased flux of [U-13C]glucose to [13C]acetyl-CoA and M2 and M4 isotopomers of tricarboxylic acid (TCA) cycle intermediates. | Tricarboxylic Acids | tafazzin, phospholipid-lysophospholipid transacylase | Mus musculus |
| 5 | The activity of pyruvate carboxylase, the predominant enzyme for anaplerotic replenishing of the TCA cycle, was elevated in TAZ-KO cells, which also exhibited increased sensitivity to the pyruvate carboxylase inhibitor phenylacetate. | Pyruvic Acid | tafazzin, phospholipid-lysophospholipid transacylase | Mus musculus |
| 6 | The activity of pyruvate carboxylase, the predominant enzyme for anaplerotic replenishing of the TCA cycle, was elevated in TAZ-KO cells, which also exhibited increased sensitivity to the pyruvate carboxylase inhibitor phenylacetate. | Tricarboxylic Acids | tafazzin, phospholipid-lysophospholipid transacylase | Mus musculus |
| 7 | The activity of pyruvate carboxylase, the predominant enzyme for anaplerotic replenishing of the TCA cycle, was elevated in TAZ-KO cells, which also exhibited increased sensitivity to the pyruvate carboxylase inhibitor phenylacetate. | phenylacetic acid | tafazzin, phospholipid-lysophospholipid transacylase | Mus musculus |
| 8 | We attributed a decreased carbon flux from glucose to acetyl-CoA in the TAZ-KO cells to a ~50% decrease in pyruvate dehydrogenase (PDH) activity, which was observed in both TAZ-KO cells and cardiac tissue from TAZ-KO mice. | Carbon | tafazzin, phospholipid-lysophospholipid transacylase | Mus musculus |
| 9 | We attributed a decreased carbon flux from glucose to acetyl-CoA in the TAZ-KO cells to a ~50% decrease in pyruvate dehydrogenase (PDH) activity, which was observed in both TAZ-KO cells and cardiac tissue from TAZ-KO mice. | Glucose | tafazzin, phospholipid-lysophospholipid transacylase | Mus musculus |
| 10 | We attributed a decreased carbon flux from glucose to acetyl-CoA in the TAZ-KO cells to a ~50% decrease in pyruvate dehydrogenase (PDH) activity, which was observed in both TAZ-KO cells and cardiac tissue from TAZ-KO mice. | Acetyl Coenzyme A | tafazzin, phospholipid-lysophospholipid transacylase | Mus musculus |
| 11 | We attributed a decreased carbon flux from glucose to acetyl-CoA in the TAZ-KO cells to a ~50% decrease in pyruvate dehydrogenase (PDH) activity, which was observed in both TAZ-KO cells and cardiac tissue from TAZ-KO mice. | Acetyl Coenzyme A | tafazzin, phospholipid-lysophospholipid transacylase | Mus musculus |
| 12 | We attributed a decreased carbon flux from glucose to acetyl-CoA in the TAZ-KO cells to a ~50% decrease in pyruvate dehydrogenase (PDH) activity, which was observed in both TAZ-KO cells and cardiac tissue from TAZ-KO mice. | Acetyl Coenzyme A | tafazzin, phospholipid-lysophospholipid transacylase | Mus musculus |
| 13 | Protein-lipid overlay experiments revealed that PDH binds to CL, and supplementing digitonin-solubilized TAZ-KO mitochondria with CL restored PDH activity to WT levels. | Digitonin | tafazzin, phospholipid-lysophospholipid transacylase | Mus musculus |