Pub. Date : 2019 Jul
PMID : 31134550
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To evaluate the discrepant toxicity, the inhibition effects of five typical MC variants (with the changed amino acid residues at position 4) target to PP1 were evaluated. | microcystin | neuropeptide Y receptor Y4 | Homo sapiens |
| 2 | Results show the hydrophobic interaction (Adda5 with PP1) and the hydrogen bonds (especially for Z4 Glu275) were positively correlated with MC toxicity, while the hydrogen bonds (Leu2 Arg96, IsoAsp3 Arg96, and IsoAsp3 Tyr134) and the ion bonds (between Mn2+ and His173/Asn124/Asp92) were negatively correlated with toxicity. | microcystin | neuropeptide Y receptor Y4 | Homo sapiens |
| 3 | By further analysis, the steric hindrance and hydrophobicity introduced by different Z4 residues affected the changes for combination area and energy of MC-PP1 complexes, leading to the discrepancies in MC toxicity. | microcystin | neuropeptide Y receptor Y4 | Homo sapiens |