Pub. Date : 1987 Jun 5
PMID : 3108256
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Swine granulosa cells respond to follicle-stimulating hormone (FSH) and the insulin-like growth factor, IGF-I (somatomedin C), with synergistic increases in progesterone production. | Progesterone | insulin like growth factor 1 | Sus scrofa |
| 2 | Swine granulosa cells respond to follicle-stimulating hormone (FSH) and the insulin-like growth factor, IGF-I (somatomedin C), with synergistic increases in progesterone production. | Progesterone | insulin like growth factor 1 | Sus scrofa |
| 3 | Conversely, exogenous sterol substrate provided in the form of low-density lipoprotein (LDL)-borne cholesterol increased the absolute magnitude of the combined actions of IGF-I and FSH by 3-6-fold. | Sterols | insulin like growth factor 1 | Sus scrofa |
| 4 | Conversely, exogenous sterol substrate provided in the form of low-density lipoprotein (LDL)-borne cholesterol increased the absolute magnitude of the combined actions of IGF-I and FSH by 3-6-fold. | Cholesterol | insulin like growth factor 1 | Sus scrofa |
| 5 | In addition, when granulosa cells were incubated with [3H]cholesteryl linoleate-labeled LDL, FSH and IGF-I synergistically augmented the intracellular accumulation of [3H]cholesterol and [3H]cholesteryl ester and the production of [3H]progesterone. | [3h]cholesteryl linoleate | insulin like growth factor 1 | Sus scrofa |
| 6 | In addition, when granulosa cells were incubated with [3H]cholesteryl linoleate-labeled LDL, FSH and IGF-I synergistically augmented the intracellular accumulation of [3H]cholesterol and [3H]cholesteryl ester and the production of [3H]progesterone. | 3h]cholesterol | insulin like growth factor 1 | Sus scrofa |
| 7 | In addition, when granulosa cells were incubated with [3H]cholesteryl linoleate-labeled LDL, FSH and IGF-I synergistically augmented the intracellular accumulation of [3H]cholesterol and [3H]cholesteryl ester and the production of [3H]progesterone. | 3h]cholesteryl ester | insulin like growth factor 1 | Sus scrofa |
| 8 | In addition, when granulosa cells were incubated with [3H]cholesteryl linoleate-labeled LDL, FSH and IGF-I synergistically augmented the intracellular accumulation of [3H]cholesterol and [3H]cholesteryl ester and the production of [3H]progesterone. | 3h]progesterone | insulin like growth factor 1 | Sus scrofa |
| 9 | Moreover, FSH and IGF-I coordinately increased the total mass of free and esterified cholesterol contained in granulosa cells. | Cholesterol | insulin like growth factor 1 | Sus scrofa |
| 10 | We conclude that FSH and IGF-I can augment absolute rates of progestin biosynthesis by granulosa cells by activating dual mechanisms: stimulation of functional cholesterol side chain cleavage activity and enhancement of effective cellular uptake and utilization of low-density lipoprotein-borne sterol substrate. | Cholesterol | insulin like growth factor 1 | Sus scrofa |
| 11 | We conclude that FSH and IGF-I can augment absolute rates of progestin biosynthesis by granulosa cells by activating dual mechanisms: stimulation of functional cholesterol side chain cleavage activity and enhancement of effective cellular uptake and utilization of low-density lipoprotein-borne sterol substrate. | Sterols | insulin like growth factor 1 | Sus scrofa |