Title : Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.

Pub. Date : 2019 Apr 17

PMID : 30994454






1 Functional Relationships(s)
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1 We report that HTT forms a transcription-coupled DNA repair (TCR) complex with RNA polymerase II subunit A (POLR2A), ataxin-3, the DNA repair enzyme polynucleotide-kinase-3"-phosphatase (PNKP), and cyclic AMP-response element-binding (CREB) protein (CBP). Cyclic AMP polynucleotide kinase 3'- phosphatase Mus musculus