Title : Nephrotoxicity instead of immunotoxicity of OTA is induced through DNMT1-dependent activation of JAK2/STAT3 signaling pathway by targeting SOCS3.

Pub. Date : 2019 Apr

PMID : 30923867






2 Functional Relationships(s)
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Protein Name
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1 DNMT inhibitor (5-Aza-2-dc), promoted SOCS3 expression, inhibited JAK2 and STAT3 expression, alleviated cytotoxicity, apoptosis and DNA damage induced by OTA at 4.0 microg/mL in PK15 cells. 5-aza-2-dc signal transducer and activator of transcription 3 Sus scrofa
2 While, in PAMs, 5-Aza-2-dc had no effects on SOCS3 expression induced by OTA at 4.0 microg/mL, but inhibited JAK2 and STAT3 expression, and alleviated cytotoxicity, apoptosis and DNA damage induced by OTA. 5-aza-2-dc signal transducer and activator of transcription 3 Sus scrofa