Pub. Date : 2019 Apr 3
PMID : 30848898
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aflatoxin B1 Induces Immunotoxicity through the DNA Methyltransferase-Mediated JAK2/STAT3 Pathway in 3D4/21 Cells. | Aflatoxin B1 | signal transducer and activator of transcription 3 | Sus scrofa |
| 2 | Inhibition of p-JAK2 and p-STAT3 by AG490 could alleviate AFB1-induced immunotoxicity. | alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide | signal transducer and activator of transcription 3 | Sus scrofa |
| 3 | Moreover, inhibition of DNMT1 and DNMT3a by 5-Aza-2dc could suppress the phosphorylation of JAK2 and STAT3. | 5-aza-2dc | signal transducer and activator of transcription 3 | Sus scrofa |
| 4 | Taken together, AFB1-induced immunotoxicity is related to the JAK2/STAT3 pathway mediated by DNMTs in 3D4/21 cells. | Aflatoxin B1 | signal transducer and activator of transcription 3 | Sus scrofa |