Pub. Date : 2019 Mar 1
PMID : 30824700
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance. | Tyrosine | phosphogluconate dehydrogenase | Homo sapiens |
| 2 | 6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). | 6-phosphogluconic acid | phosphogluconate dehydrogenase | Homo sapiens |
| 3 | 6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). | 6-phosphogluconic acid | phosphogluconate dehydrogenase | Homo sapiens |
| 4 | 6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). | ribulose 5-phosphate | phosphogluconate dehydrogenase | Homo sapiens |
| 5 | 6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). | ribulose 5-phosphate | phosphogluconate dehydrogenase | Homo sapiens |
| 6 | 6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). | NADP | phosphogluconate dehydrogenase | Homo sapiens |
| 7 | 6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). | NADP | phosphogluconate dehydrogenase | Homo sapiens |
| 8 | 6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). | Pentosephosphates | phosphogluconate dehydrogenase | Homo sapiens |
| 9 | 6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). | Pentosephosphates | phosphogluconate dehydrogenase | Homo sapiens |
| 10 | Here we show that upon EGFR activation, 6PGD is phosphorylated at tyrosine (Y) 481 by Src family kinase Fyn. | Tyrosine | phosphogluconate dehydrogenase | Homo sapiens |
| 11 | This phosphorylation enhances 6PGD activity by increasing its binding affinity to NADP+ and therefore activates the PPP for NADPH and ribose-5-phosphate, which consequently detoxifies intracellular reactive oxygen species (ROS) and accelerates DNA synthesis. | NADP | phosphogluconate dehydrogenase | Homo sapiens |
| 12 | This phosphorylation enhances 6PGD activity by increasing its binding affinity to NADP+ and therefore activates the PPP for NADPH and ribose-5-phosphate, which consequently detoxifies intracellular reactive oxygen species (ROS) and accelerates DNA synthesis. | NADP | phosphogluconate dehydrogenase | Homo sapiens |
| 13 | This phosphorylation enhances 6PGD activity by increasing its binding affinity to NADP+ and therefore activates the PPP for NADPH and ribose-5-phosphate, which consequently detoxifies intracellular reactive oxygen species (ROS) and accelerates DNA synthesis. | ribose-5-phosphate | phosphogluconate dehydrogenase | Homo sapiens |
| 14 | This phosphorylation enhances 6PGD activity by increasing its binding affinity to NADP+ and therefore activates the PPP for NADPH and ribose-5-phosphate, which consequently detoxifies intracellular reactive oxygen species (ROS) and accelerates DNA synthesis. | Reactive Oxygen Species | phosphogluconate dehydrogenase | Homo sapiens |
| 15 | This phosphorylation enhances 6PGD activity by increasing its binding affinity to NADP+ and therefore activates the PPP for NADPH and ribose-5-phosphate, which consequently detoxifies intracellular reactive oxygen species (ROS) and accelerates DNA synthesis. | Reactive Oxygen Species | phosphogluconate dehydrogenase | Homo sapiens |