Title : Thiazolidine derivatives as potent inhibitors specific for prolyl endopeptidase.

Pub. Date : 1988 Oct

PMID : 3071531






1 Functional Relationships(s)
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1 Thus, N-benzyloxycarbonyl-L-thioprolyl-thiazolidine (Z-Thiopro-thiazolidine) and Z-L-Thiopro-L-thioprolinal showed Ki values of 0.36 and 0.01 nM, respectively, for prolyl endopeptidase from bovine brain; both values were significantly lower than that of Z-Pro-prolinal (Ki, 3.7 nM). N-benzyloxycarbonylprolylprolinal prolyl endopeptidase Bos taurus