Pub. Date : 2019 Mar 15
PMID : 30699330
5 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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1 | AIMS: The heterodimerization of angiotensin II receptors (AT1R and AT2R) with adiponectin receptor AdipoR1 and AdipoR2 may instigate high glucose (HG)-induced renal tubulointerstitial injury. | Glucose | adiponectin receptor 1 | Rattus norvegicus | ||
2 | Diabetic rats treated with or without the intravenous injection of AdipoR1 siRNA were intragastrically administered with 5 mg/kg/d telmisartan or a vehicle for 12 weeks. | Telmisartan | adiponectin receptor 1 | Rattus norvegicus | ||
3 | Furthermore, diabetic rats exhibited increased AT1R-AdipoR1 heterodimers in the renal tubular compartment, which could be attenuated by telmisartan treatment, accompanied by a decrease in the expression level of cytokines MIP-1alpha, ICAM-1 and MCP-1. | Telmisartan | adiponectin receptor 1 | Rattus norvegicus | ||
4 | Telmisartan could inhibit HG-induced AT1R-AdipoR1 dimerization, downregulate the expression levels of inflammatory cytokines, and alleviate cell apoptosis in NRK-52E cells. | Telmisartan | adiponectin receptor 1 | Rattus norvegicus | ||
5 | Furthermore, AdipoR1 knockdown could abate the renoprotective benefits of telmisartan. | Telmisartan | adiponectin receptor 1 | Rattus norvegicus |