Title : Telmisartan attenuates diabetic nephropathy progression by inhibiting the dimerization of angiotensin type-1 receptor and adiponectin receptor-1.

Pub. Date : 2019 Mar 15

PMID : 30699330






5 Functional Relationships(s)
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1 AIMS: The heterodimerization of angiotensin II receptors (AT1R and AT2R) with adiponectin receptor AdipoR1 and AdipoR2 may instigate high glucose (HG)-induced renal tubulointerstitial injury. Glucose adiponectin receptor 1 Rattus norvegicus
2 Diabetic rats treated with or without the intravenous injection of AdipoR1 siRNA were intragastrically administered with 5 mg/kg/d telmisartan or a vehicle for 12 weeks. Telmisartan adiponectin receptor 1 Rattus norvegicus
3 Furthermore, diabetic rats exhibited increased AT1R-AdipoR1 heterodimers in the renal tubular compartment, which could be attenuated by telmisartan treatment, accompanied by a decrease in the expression level of cytokines MIP-1alpha, ICAM-1 and MCP-1. Telmisartan adiponectin receptor 1 Rattus norvegicus
4 Telmisartan could inhibit HG-induced AT1R-AdipoR1 dimerization, downregulate the expression levels of inflammatory cytokines, and alleviate cell apoptosis in NRK-52E cells. Telmisartan adiponectin receptor 1 Rattus norvegicus
5 Furthermore, AdipoR1 knockdown could abate the renoprotective benefits of telmisartan. Telmisartan adiponectin receptor 1 Rattus norvegicus