Title : Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor.

Pub. Date : 2019 Feb 1

PMID : 30580239






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Among them, Ly93 as one of the most potent inhibitors exhibited IC50 values of 91 nM and 133.9 muM against purified SMS2 and SMS1 respectively. Ly93 sphingomyelin synthase 1 Mus musculus
2 The selectivity ratio of Ly93 was more than 1400-fold for purified SMS2 over SMS1. Ly93 sphingomyelin synthase 1 Mus musculus