Pub. Date : 2019 Mar
PMID : 30462528
15 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Ergosterol interacts with Sey1p to promote atlastin-mediated endoplasmic reticulum membrane fusion in Saccharomyces cerevisiae. | Ergosterol | dynamin-like GTPase SEY1 | Saccharomyces cerevisiae S288C | ||
| 2 | Although ergosterol, the major sterol in yeast, is essential for fusion of Sey1p (yeast atlastin)-containing liposomes with an ER-mimicking lipid composition, fusion of phosphatidylcholine/phosphatidylserine liposomes does not require sterols. | Ergosterol | dynamin-like GTPase SEY1 | Saccharomyces cerevisiae S288C | ||
| 3 | Although ergosterol, the major sterol in yeast, is essential for fusion of Sey1p (yeast atlastin)-containing liposomes with an ER-mimicking lipid composition, fusion of phosphatidylcholine/phosphatidylserine liposomes does not require sterols. | Sterols | dynamin-like GTPase SEY1 | Saccharomyces cerevisiae S288C | ||
| 4 | Importantly, disruption of sterol-binding motifs in the transmembrane regions of Sey1p markedly reduced ER fusion. | Sterols | dynamin-like GTPase SEY1 | Saccharomyces cerevisiae S288C | ||
| 5 | Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p. | Ergosterol | dynamin-like GTPase SEY1 | Saccharomyces cerevisiae S288C | ||
| 6 | Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p. | Ergosterol | dynamin-like GTPase SEY1 | Saccharomyces cerevisiae S288C | ||
| 7 | Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p. | Ergosterol | dynamin-like GTPase SEY1 | Saccharomyces cerevisiae S288C | ||
| 8 | Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p. | Ergosterol | dynamin-like GTPase SEY1 | Saccharomyces cerevisiae S288C | ||
| 9 | Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p. | Ergosterol | dynamin-like GTPase SEY1 | Saccharomyces cerevisiae S288C | ||
| 10 | Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p. | Ergosterol | dynamin-like GTPase SEY1 | Saccharomyces cerevisiae S288C | ||
| 11 | Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p. | Ergosterol | dynamin-like GTPase SEY1 | Saccharomyces cerevisiae S288C | ||
| 12 | Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p. | Ergosterol | dynamin-like GTPase SEY1 | Saccharomyces cerevisiae S288C | ||
| 13 | Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p. | Ergosterol | dynamin-like GTPase SEY1 | Saccharomyces cerevisiae S288C | ||
| 14 | Ergosterol interacts with Sey1p to promote atlastin-mediated endoplasmic reticulum membrane fusion in Saccharomyces cerevisiae. | Ergosterol | dynamin-like GTPase SEY1 | Saccharomyces cerevisiae S288C | ||
| 15 | Ergosterol interacts with Sey1p to promote atlastin-mediated endoplasmic reticulum membrane fusion in Saccharomyces cerevisiae. | atlastin | dynamin-like GTPase SEY1 | Saccharomyces cerevisiae S288C | ||