Title : Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.

Pub. Date : 2019 Apr

PMID : 30335591






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Trehalose upregulated genes for the TFEB target and regulator Ppargc1a, lysosomal hydrolases and membrane proteins (Ctsb, Gla, Lamp2a, Mcoln1, Tpp1) and several autophagy-related components (Becn1, Atg10, Atg12, Sqstm1/p62, Map1lc3b, Hspb8 and Bag3) mostly in a PPP3- and TFEB-dependent manner. Trehalose autophagy related 12 Homo sapiens