Title : DNA Damage, Liver Injury, and Tumorigenesis: Consequences of DDX3X Loss.

Pub. Date : 2019 Feb

PMID : 30297359






1 Functional Relationships(s)
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1 Loss of Ddx3x led to decreased levels of DNA repair factors, which contributed to an accumulation of unrepaired DNA damage, replication stress, and eventually, spontaneous liver tumors and DEN-induced HCCs in Alb-Cre/+;Ddx3xflox/flox mice. Diethylnitrosamine holocytochrome c synthetase Mus musculus