Title : In vivo determinations of Ki values for angiotensin converting enzyme inhibitors.

Pub. Date : 1986

PMID : 3028064






5 Functional Relationships(s)
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1 We present two methods for calculating Ki values of angiotensin converting enzyme (ACE) inhibitors, such as captopril, in anesthetized or conscious rabbits. Captopril angiotensin-converting enzyme Oryctolagus cuniculus
2 We present two methods for calculating Ki values of angiotensin converting enzyme (ACE) inhibitors, such as captopril, in anesthetized or conscious rabbits. Captopril angiotensin-converting enzyme Oryctolagus cuniculus
3 Both methods are based on indicator-dilution type determinations of single pass transpulmonary metabolism of the ACE substrate benzoyl-phe-ala-pro (BPAP). benzoylphenylalanyl-alanyl-proline angiotensin-converting enzyme Oryctolagus cuniculus
4 Both methods are based on indicator-dilution type determinations of single pass transpulmonary metabolism of the ACE substrate benzoyl-phe-ala-pro (BPAP). benzoylphenylalanyl-alanyl-proline angiotensin-converting enzyme Oryctolagus cuniculus
5 The first method involves two determinations of Michaelis-Menten constants Km and Amax (product of Vmax and lung capillary plasma volume) of endothelial-bound ACE for BPAP. benzoylphenylalanyl-alanyl-proline angiotensin-converting enzyme Oryctolagus cuniculus