Title : Hypotaurine Is a Substrate of GABA Transporter Family Members GAT2/Slc6a13 and TAUT/Slc6a6.

Pub. Date : 2018

PMID : 30270321






14 Functional Relationships(s)
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1 Hypotaurine Is a Substrate of GABA Transporter Family Members GAT2/Slc6a13 and TAUT/Slc6a6. hypotaurine solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 Mus musculus
2 Hypotaurine Is a Substrate of GABA Transporter Family Members GAT2/Slc6a13 and TAUT/Slc6a6. hypotaurine solute carrier family 6 (neurotransmitter transporter, GABA), member 13 Mus musculus
3 Hypotaurine Is a Substrate of GABA Transporter Family Members GAT2/Slc6a13 and TAUT/Slc6a6. hypotaurine solute carrier family 6 (neurotransmitter transporter, taurine), member 6 Mus musculus
4 Hypotaurine Is a Substrate of GABA Transporter Family Members GAT2/Slc6a13 and TAUT/Slc6a6. hypotaurine solute carrier family 6 (neurotransmitter transporter, taurine), member 6 Mus musculus
5 TAUT and GAT2 showed strong [14C]hypotaurine uptake activity, while BGT1 showed moderate activity, and GAT1 and GAT3 showed slight but significant activity. hypotaurine solute carrier family 6 (neurotransmitter transporter, taurine), member 6 Mus musculus
6 TAUT and GAT2 showed strong [14C]hypotaurine uptake activity, while BGT1 showed moderate activity, and GAT1 and GAT3 showed slight but significant activity. hypotaurine solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 Mus musculus
7 TAUT and GAT2 showed strong [14C]hypotaurine uptake activity, while BGT1 showed moderate activity, and GAT1 and GAT3 showed slight but significant activity. hypotaurine solute carrier family 6 (neurotransmitter transporter, GABA), member 1 Mus musculus
8 TAUT and GAT2 showed strong [14C]hypotaurine uptake activity, while BGT1 showed moderate activity, and GAT1 and GAT3 showed slight but significant activity. hypotaurine solute carrier family 6 (neurotransmitter transporter, GABA), member 11 Mus musculus
9 Mouse TAUT and GAT2 both showed Michaelis constants of 11 microM for hypotaurine uptake. hypotaurine solute carrier family 6 (neurotransmitter transporter, taurine), member 6 Mus musculus
10 Mouse TAUT and GAT2 both showed Michaelis constants of 11 microM for hypotaurine uptake. hypotaurine solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 Mus musculus
11 GAT2-expressing cells pretreated with hypotaurine showed resistance to H2O2-induced oxidative stress. hypotaurine solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 Mus musculus
12 These results suggest that under physiological conditions, TAUT and GAT2 would be major contributors to hypotaurine transfer across the plasma membrane, and that uptake of hypotaurine via GAT2 contributes to the cellular resistance to oxidative stress. hypotaurine solute carrier family 6 (neurotransmitter transporter, taurine), member 6 Mus musculus
13 These results suggest that under physiological conditions, TAUT and GAT2 would be major contributors to hypotaurine transfer across the plasma membrane, and that uptake of hypotaurine via GAT2 contributes to the cellular resistance to oxidative stress. hypotaurine solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 Mus musculus
14 These results suggest that under physiological conditions, TAUT and GAT2 would be major contributors to hypotaurine transfer across the plasma membrane, and that uptake of hypotaurine via GAT2 contributes to the cellular resistance to oxidative stress. hypotaurine solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 Mus musculus