Title : Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1.

Pub. Date : 2019 Jan

PMID : 30243987






5 Functional Relationships(s)
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Protein Name
Organism
1 Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated. Samarium sphingomyelin synthase 1 Mus musculus
2 Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated. Ceramides sphingomyelin synthase 1 Mus musculus
3 Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated. Ceramides sphingomyelin synthase 1 Mus musculus
4 Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated. Phosphatidylcholines sphingomyelin synthase 1 Mus musculus
5 Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated. Phosphatidylcholines sphingomyelin synthase 1 Mus musculus