Pub. Date : 2019 Jan
PMID : 30178500
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | NPRL2 enhances autophagy and the resistance to Everolimus in castration-resistant prostate cancer. | Everolimus | NPR2 like, GATOR1 complex subunit | Mus musculus |
2 | However, the role of NPRL2 in regulating the resistance to Everolimus (EVS), an inhibitor of the mTOR, in castration-resistant prostate cancer (CRPC) is still unclear. | Everolimus | NPR2 like, GATOR1 complex subunit | Mus musculus |
3 | Therefore, in present study, we evaluated the role of NPRL2 and its potential resistance to EVS in CRPC. | Everolimus | NPR2 like, GATOR1 complex subunit | Mus musculus |
4 | METHODS: NPRL2 expression levels in prostate tissues, including benign prostate hyperplasia (BPH) tissues, primary prostate cancer (PCa) tissues, CRPC tissues, and several PCa cell lines (LNCaP, PC3, and enzalutamide-resistant LNCaP, named LNPER) were be evaluated by immunohistochemistry, RT-PCR, and Western blot. | enzalutamide | NPR2 like, GATOR1 complex subunit | Mus musculus |
5 | Lastly, relationship between NPRL2 expression level and the efficacy of EVS were evaluated in mice tumor xenograft models. | Everolimus | NPR2 like, GATOR1 complex subunit | Mus musculus |
6 | NPRL2 over-expression promoted the proliferation, resistance to EVS, and NPRL2 silencing inhibited proliferation, enhanced sensitivity to EVS in PC3 and LNPER cells. | Everolimus | NPR2 like, GATOR1 complex subunit | Mus musculus |
7 | Moreover, NPRL2-silencing increased the activity of mTOR signaling, and the autophagy attenuation induced by NPRL2-silencing in EVS-treated CRPC cells was associated with the increase of apoptosis. | Everolimus | NPR2 like, GATOR1 complex subunit | Mus musculus |
8 | Moreover, NPRL2-silencing increased the activity of mTOR signaling, and the autophagy attenuation induced by NPRL2-silencing in EVS-treated CRPC cells was associated with the increase of apoptosis. | Everolimus | NPR2 like, GATOR1 complex subunit | Mus musculus |
9 | In addition, the growth prevention of NPRL2-silencing LNPER tumors in mice induced by EVS-treatment was associated with the autophagy attenuation and apoptosis increase. | Everolimus | NPR2 like, GATOR1 complex subunit | Mus musculus |
10 | The high levels of NPRL2 expression in CRPC promote resistance to EVS by enhancing autophagy. | Everolimus | NPR2 like, GATOR1 complex subunit | Mus musculus |
11 | NPRL2 may be a new therapeutic target for intervention of CRPC and a biomarker for predicting resistance to EVS in CRPC. | Everolimus | NPR2 like, GATOR1 complex subunit | Mus musculus |