Pub. Date : 2018 Oct
PMID : 30117016
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | miR-129-5p inhibits gemcitabine resistance and promotes cell apoptosis of bladder cancer cells by targeting Wnt5a. | gemcitabine | microRNA 1295a | Homo sapiens |
| 2 | This study was aimed to investigate the potential role of miR-129-5p in the development of gemcitabine resistance in bladder cancer cells and its underlying mechanism. | gemcitabine | microRNA 1295a | Homo sapiens |
| 3 | RESULTS: We found that down-regulated miR-129-5p level contributed to gemcitabine resistance in bladder cancer cells and tissues. | gemcitabine | microRNA 1295a | Homo sapiens |
| 4 | We also observed restoration of miR-129-5p could significantly increase cell sensitivity to gemcitabine and promote cell apoptosis. | gemcitabine | microRNA 1295a | Homo sapiens |
| 5 | Mechanism analysis revealed that Wnt5a is a direct target gene of miR-129-5p and knock-down of Wnt5a reversed gemcitabine resistance. | gemcitabine | microRNA 1295a | Homo sapiens |
| 6 | CONCLUSIONS: Taken together, our findings indicate that miR-129-5p and Wnt5a may be novel therapeutic targets for overcoming gemcitabine resistance in bladder cancer treatment. | gemcitabine | microRNA 1295a | Homo sapiens |