Title : Leukotriene A4. Enzymatic conversion into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid by mouse liver cytosolic epoxide hydrolase.

Pub. Date : 1986 May 15

PMID : 3009453






2 Functional Relationships(s)
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1 A purified cytosolic epoxide hydrolase from mouse liver also transformed leukotriene A4 into a 5,6-dihydroxyeicosatetraenoic acid with the same physico-chemical characteristics as the compound formed in crude cytosol, but not into leukotriene B4, a compound previously reported to be formed in liver cytosol (Haeggstrom, J., Radmark, O., and Fitzpatrick, F.A. Leukotriene A4 epoxide hydrolase 2, cytoplasmic Mus musculus
2 These findings suggest a role for leukotriene A4 as an endogenous substrate for cytosolic epoxide hydrolase, an enzyme earlier characterized by xenobiotic substrates. Leukotriene A4 epoxide hydrolase 2, cytoplasmic Mus musculus