Title : Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ.

Pub. Date : 2019 Jan

PMID : 30082911






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ. Calcium tafazzin, phospholipid-lysophospholipid transacylase Mus musculus
2 Here we found in an unbiased screen of 1650 compounds that amlodipine is able to inhibit survival of GBM cells by suppressing YAP/TAZ activities. Amlodipine tafazzin, phospholipid-lysophospholipid transacylase Mus musculus
3 Amlodipine as well as approaches that cause store depletion and activate SOCE trigger phosphorylation and activation of Lats1/2, which in turn phosphorylate YAP/TAZ and prevent their accumulation in the cell nucleus. Amlodipine tafazzin, phospholipid-lysophospholipid transacylase Mus musculus