Title : Matrine induces senescence of human glioblastoma cells through suppression of the IGF1/PI3K/AKT/p27 signaling pathway.

Pub. Date : 2018 Sep

PMID : 30079478






2 Functional Relationships(s)
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1 Exposure of cells to a small molecule activating AKT (SC79) and recombinant IGF1 led to a reduced number of senescent SA-beta-gal-positive cells in the presence of matrine. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid AKT serine/threonine kinase 1 Homo sapiens
2 Exposure of cells to a small molecule activating AKT (SC79) and recombinant IGF1 led to a reduced number of senescent SA-beta-gal-positive cells in the presence of matrine. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid insulin like growth factor 1 Homo sapiens