Pub. Date : 2018 Jul
PMID : 29988567
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although chronic therapy with metformin fails to achieve recovery from hyperglycemia, a key feature of diabetes in middle-aged diabetic mice, it improves hippocampal-dependent spatial memory functions accompanied by increased phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), atypical protein kinase C zeta (aPKC zeta), and insulin receptor substrate 1 (IRS1) at selective serine residues in the hippocampus. | Metformin | protein kinase C, zeta | Mus musculus |
| 2 | Although chronic therapy with metformin fails to achieve recovery from hyperglycemia, a key feature of diabetes in middle-aged diabetic mice, it improves hippocampal-dependent spatial memory functions accompanied by increased phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), atypical protein kinase C zeta (aPKC zeta), and insulin receptor substrate 1 (IRS1) at selective serine residues in the hippocampus. | Metformin | protein kinase C, zeta | Mus musculus |
| 3 | Our findings suggest that signaling networks acting through long-term metformin-stimulated phosphorylation of AMPK, aPKC zeta/lambda, and IRS1 serine sites contribute to neuroprotective effects on hippocampal neurogenesis and cognitive function independent of a hypoglycemic effect. | Metformin | protein kinase C, zeta | Mus musculus |