Title : Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate.

Pub. Date : 2018 Jul 6

PMID : 29980677






3 Functional Relationships(s)
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Protein Name
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1 Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate. kinesin-13 kinesin family member 2A Homo sapiens
2 Here we report the crystal structure of a catalytically active kinesin-13 monomer (Kif2A) in complex with two bent alphabeta-tubulin heterodimers in a head-to-tail array, providing a view of these interactions. kinesin-13 kinesin family member 2A Homo sapiens
3 AMPPNP-bound Kif2A can form stable complexes with tubulin in solution and trigger MT depolymerization. Adenylyl Imidodiphosphate kinesin family member 2A Homo sapiens