Title : Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis.

Pub. Date : 2018 Aug

PMID : 29614330






7 Functional Relationships(s)
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1 Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis. Ketamine cytochrome P450 family 3 subfamily A member 94 Equus caballus
2 Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis. Medetomidine cytochrome P450 family 3 subfamily A member 94 Equus caballus
3 Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis. Diazepam cytochrome P450 family 3 subfamily A member 94 Equus caballus
4 Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis. Methadone cytochrome P450 family 3 subfamily A member 94 Equus caballus
5 Enzyme kinetics for ketamine N-demethylation were determined using equine CYP3A94, CYP3A95 and CYP3A97, and the effect of medetomidine, diazepam and methadone on the ketamine metabolism was studied in vitro. Ketamine cytochrome P450 family 3 subfamily A member 94 Equus caballus
6 In contrast to diazepam and methadone, the alpha2-recepor agonist medetomidine diminished the norketamine formation significantly in CYP3A94 and CYP3A97. Medetomidine cytochrome P450 family 3 subfamily A member 94 Equus caballus
7 In contrast to diazepam and methadone, the alpha2-recepor agonist medetomidine diminished the norketamine formation significantly in CYP3A94 and CYP3A97. norketamine cytochrome P450 family 3 subfamily A member 94 Equus caballus