Title : Glutathione-induced amino-activatable micellar photosensitization platform for synergistic redox modulation and photodynamic therapy.

Pub. Date : 2018 May 1

PMID : 29589866






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Subsequently, pheophorbide a (PhA) was encapsulated as the model photosensitizer. pheophorbide a lamin B receptor Homo sapiens
2 Upon internalization by HepG2 cells, the strongly electron-withdrawing 2,4-dinitrobenzenesulfonyl groups on the PADEE segments were readily cleaved by GSH, during which time the secondary amino groups (pKb = 11.32) were recovered and completely protonated, leading to disassembly of the micelles and rapid release of PhA. 2,4-dinitrobenzenesulfonyl lamin B receptor Homo sapiens
3 Upon internalization by HepG2 cells, the strongly electron-withdrawing 2,4-dinitrobenzenesulfonyl groups on the PADEE segments were readily cleaved by GSH, during which time the secondary amino groups (pKb = 11.32) were recovered and completely protonated, leading to disassembly of the micelles and rapid release of PhA. Glutathione lamin B receptor Homo sapiens