Pub. Date : 2018 Apr 15
PMID : 29534964
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibiting 6-phosphogluconate dehydrogenase reverses doxorubicin resistance in anaplastic thyroid cancer via inhibiting NADPH-dependent metabolic reprogramming. | Doxorubicin | phosphogluconate dehydrogenase | Homo sapiens |
| 2 | Inhibiting 6-phosphogluconate dehydrogenase reverses doxorubicin resistance in anaplastic thyroid cancer via inhibiting NADPH-dependent metabolic reprogramming. | NADP | phosphogluconate dehydrogenase | Homo sapiens |
| 3 | In our work, we identified that 6-phosphogluconate dehydrogenase (6PGD) is critically involved in the development of ATC resistance to doxorubicin. | Doxorubicin | phosphogluconate dehydrogenase | Homo sapiens |
| 4 | In our work, we identified that 6-phosphogluconate dehydrogenase (6PGD) is critically involved in the development of ATC resistance to doxorubicin. | Doxorubicin | phosphogluconate dehydrogenase | Homo sapiens |
| 5 | We found that 6PGD mRNA, protein and enzyme activity levels are significantly upregulated in ATC cells during the prolonged exposure to doxorubicin in a time-dependent manner. | Doxorubicin | phosphogluconate dehydrogenase | Homo sapiens |
| 6 | 6PGD inhibition by genetic and pharmacological approaches significantly inhibits growth and survival of ATC cells that are highly resistant to doxorubicin. | Doxorubicin | phosphogluconate dehydrogenase | Homo sapiens |
| 7 | Consistently, 6PGD inhibition also sensitizes ATC cells to doxorubicin treatment. | Doxorubicin | phosphogluconate dehydrogenase | Homo sapiens |
| 8 | Of note, we observed the decreased level of NADPH, NADH and enzymatic activity of sirtuin-1 in response to 6PGD inhibition in doxorubicin-resistant ATC cells. | NADP | phosphogluconate dehydrogenase | Homo sapiens |
| 9 | Of note, we observed the decreased level of NADPH, NADH and enzymatic activity of sirtuin-1 in response to 6PGD inhibition in doxorubicin-resistant ATC cells. | NAD | phosphogluconate dehydrogenase | Homo sapiens |
| 10 | Of note, we observed the decreased level of NADPH, NADH and enzymatic activity of sirtuin-1 in response to 6PGD inhibition in doxorubicin-resistant ATC cells. | Doxorubicin | phosphogluconate dehydrogenase | Homo sapiens |
| 11 | Lactate level was also reduced by 6PGD inhibition. | Lactic Acid | phosphogluconate dehydrogenase | Homo sapiens |
| 12 | All these indicate that 6PGD inhibition disrupts metabolic reprogramming in doxorubicin-resistant ATC cells. | Doxorubicin | phosphogluconate dehydrogenase | Homo sapiens |
| 13 | Our work demonstrates 6PGD activation-mediated resistance in response to doxorubicin and provides an alternative therapeutic strategy to overcome resistance to chemotherapy for ATC treatment. | Doxorubicin | phosphogluconate dehydrogenase | Homo sapiens |