Pub. Date : 2018 Apr
PMID : 29471107
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PICK1 deficiency exacerbates sepsis-associated acute lung injury and impairs glutathione synthesis via reduction of xCT. | Glutathione | protein interacting with C kinase 1 | Mus musculus |
| 2 | A marked elevation of PICK1 mRNA and protein level were demonstrated in lung tissue, which was accompanied by increased production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and consumption of glutathione (GSH). | Reactive Oxygen Species | protein interacting with C kinase 1 | Mus musculus |
| 3 | A marked elevation of PICK1 mRNA and protein level were demonstrated in lung tissue, which was accompanied by increased production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and consumption of glutathione (GSH). | Reactive Oxygen Species | protein interacting with C kinase 1 | Mus musculus |
| 4 | A marked elevation of PICK1 mRNA and protein level were demonstrated in lung tissue, which was accompanied by increased production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and consumption of glutathione (GSH). | Reactive Nitrogen Species | protein interacting with C kinase 1 | Mus musculus |
| 5 | A marked elevation of PICK1 mRNA and protein level were demonstrated in lung tissue, which was accompanied by increased production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and consumption of glutathione (GSH). | Reactive Nitrogen Species | protein interacting with C kinase 1 | Mus musculus |
| 6 | A marked elevation of PICK1 mRNA and protein level were demonstrated in lung tissue, which was accompanied by increased production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and consumption of glutathione (GSH). | Glutathione | protein interacting with C kinase 1 | Mus musculus |
| 7 | A marked elevation of PICK1 mRNA and protein level were demonstrated in lung tissue, which was accompanied by increased production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and consumption of glutathione (GSH). | Glutathione | protein interacting with C kinase 1 | Mus musculus |
| 8 | Alterations of lung GSH content induced PICK1 level change after CLP challenge. | Glutathione | protein interacting with C kinase 1 | Mus musculus |
| 9 | Taken together, PICK1 plays a pivotal role in sepsis-induced ALI by regulating GSH synthesis via affecting the substrate-specific subunit of lung cystine/glutamate transporter, xCT. | Glutathione | protein interacting with C kinase 1 | Mus musculus |