Pub. Date : 2018 Jan 23
PMID : 29361979
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we aimed to establish an efficient protocol for maximizing generation of PDX1+/NKX6.1+ PPs from human pluripotent stem cells (hPSCs). | pps | NK6 homeobox 1 | Homo sapiens |
| 2 | These dissociated cells were subjected to an augmented duration of retinoid and fibroblast growth factor (FGF)10 signaling to induce higher PDX1 and NKX6.1 expression. | Retinoids | NK6 homeobox 1 | Homo sapiens |
| 3 | CONCLUSIONS: We provide a novel technique that facilitates appropriate cellular rearrangement in monolayer culture to yield a high proportion of PDX1+/NKX6.1+ PPs with an elevated self-replicating capacity, thereby aiding scalable production of functional beta cells from hPSCs in vitro. | pps | NK6 homeobox 1 | Homo sapiens |