Title : The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells.

Pub. Date : 2018 Feb

PMID : 29345285






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 N6-methyladenosine (m6A) is the most abundant epitranscriptome modification in mammalian mRNA. N-methyladenosine methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Homo sapiens
2 Although morphologic and proliferative changes were unaffected, METTL3-depleted cells showed higher sensitivity to anticancer reagents such as gemcitabine, 5-fluorouracil, cisplatin and irradiation. gemcitabine methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Homo sapiens
3 Although morphologic and proliferative changes were unaffected, METTL3-depleted cells showed higher sensitivity to anticancer reagents such as gemcitabine, 5-fluorouracil, cisplatin and irradiation. Fluorouracil methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Homo sapiens
4 Although morphologic and proliferative changes were unaffected, METTL3-depleted cells showed higher sensitivity to anticancer reagents such as gemcitabine, 5-fluorouracil, cisplatin and irradiation. Cisplatin methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Homo sapiens